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There have been many software programs that have provided simulations for the performance and operation of the Environmental Control and Life Support Subsystems (ECLSS) in the International Space Station (ISS) and in the Space Shuttle. These programs have been applied for purposes in system analysis, flight analysis, and ECLSS studies. Flight and system analysis tasks are deemed important. Therefore, more manpower and resources added for such work is considered beneficial. System analysis covers design and trouble-shooting, the validation of Flight Rules, and the contingency analysis. During the engineering design phase, ECLSS modelers predict the performance and interaction of units in a process train. Simulation results can be useful in estimating equipment sizes and costs. This article has also used two examples to illustrate that many Flight Rules need to be validated using properly selected integrated programs.