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The impact on the water recovery and reclamation system resulting from laundry operations has been the primary obstacle to the implementation of a laundry capable for long duration space missions. Such an onboard system can provide improved housekeeping effectiveness and crew health maintenance aspects. Electrochemically generated ozone was used as a laundry (cleaning) agent under simulated washing conditions and compared with Tide® and dodecynlbenzoicsuccinic acid (DBSA). Three aspects were studied: (i) cleaning ability; (ii) disinfection potential; and, (iii) impact on the resulting laundry water. In most instances, ozone provided a detergent-like cleaning ability that was as good as, or better than, Tide® or DBSA. Ozone was a superior disinfectant and, more importantly, had a low impact on the laundry wash water in terms of its potential for recycling.