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The Advanced Animal Habitat (AAH) represents the next generation of Space Station based animal research facilities. Care has been taken to protect the ISS crew from exposure to the hazardous biological materials contained within the AAH. These materials include rat feces, urine, dander, and odor. The approach to containing biological materials relies on collecting the solid and liquid waste, providing physical barriers between the waste and the crew environment, maintaining negative pressure within the specimen environment with respect to the crew environment, and providing odor filtration of air exchanged between the specimen and crew environments. These protections will be in place during all modes of AAH operation.

The design of reliable systems is especially important when they are intended for use on the International Space Station (ISS). Limits on crew time and the sensitive nature of experiments being performed require that the systems used to support those experiments have a very low probability of failure. The Plant Research Unit (PRU) has very strict reliability requirements and thus provides a good example of how the challenge of designing reliable systems can be met.

The International Space Station (ISS) presents unique challenges in the field of maintainability engineering. Due to limited training time on earth and crew time in space, systems must be designed for ease of operation and maintenance. The Plant Research Unit (PRU), an advanced plant growth facility, is required to operate on orbit with minimal crew interaction for maintenance. The PRU has been allotted one hour per increment for corrective maintenance, which consists of replacing Orbital Replacement Units (ORU) or incorporating workarounds. Designing highly maintainable systems is not possible without incorporating the principles of human factors engineering. The PRU has met the strict crew time requirements by combining those principles with maintainability engineering analysis techniques and then integrating them in the design process.