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Monitoring and preserving state-of-health of high-voltage battery packs in electrified road vehicles currently represents an open and growing research topic. When predicting high-voltage battery lifetime, most current literature assumes a uniform temperature distribution among the different cells of the pack. Nevertheless, temperature has been demonstrated having a key impact on cell lifetime, and different cells of the same battery pack typically exhibit different temperature profiles over time, e.g. due to their position within the pack. Following these considerations, this paper aims at assessing the effect of temperature distribution on the predicted lifetime of cells belonging to the same battery pack. To this end, a throughput-based numerical cell ageing model is firstly selected due to its reasonable compromise between accuracy and computational efficiency.