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Fuel cells are considered one of the promising technologies as possible replacement of Internal Combustion Engine (ICE) for the transportation sector due to their high efficiency, ultra-low (or zero) emissions and for the higher drive range. The Membrane Electrode Assembly (MEA) is what mainly influences the Fuel Cell FC performance, durability, and cost. In PEMFC the proton conductivity of the membrane is a function of the humidification level of the FC membrane, hence the importance of keeping the membrane properly humidified to achieve the best possible fuel cell performance. To have the optimal water content inside the fuel cell’s membrane several strategies could be adopted, dealing with the use of external device (such as membrane humidifier) or to adopt an optimal set of parameters (gas flow rate and temperature for example) to use the water produced at fuel cell cathode as humidity source. The aim of this paper is to study the behavior of a FC vehicle humidification system.