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International Space Station (ISS) Payload Engineering Integration (PEI) organization adopted the advanced computation and simulation technology to develop integrated electrical system models based on the test data of various sub-units. This system model was used end-to-end to mitigate system risk for the integrated Space Shuttle Pre-launch and Landing configurations. The Space Shuttle carries the Multi-Purpose Logistics Module (MPLM), a pressurize transportation carrier, and the Laboratory Freezer for ISS, a freezer rack for storage and transport of science experiments from/to the ISS, is carried inside the MPLM. An end-to-end electrical system model for Space Shuttle Pre-Launch and Landing configurations, including the MPLM and Freezer, provided vital information for integrated electrical testing and to assess Mission success. The Pre-Launch and Landing configurations have different power supplies and cables to provide the power for the MPLM and the Freezer.