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Accident statistics have shown that older and obese occupants are less adaptable to existing vehicle occupant restraint systems than ordinary middle-aged male occupants, and tend to have higher injury risk in vehicle crashes. However, the current research on injury mechanism of aging and obese occupants in vehicle frontal impacts is scarce. This paper focuses on the optimization design method of occupant restraint system parameters for specific body type characteristics. Three parameters, namely the force limit value of the force limiter in the seat belt, pretensioner preload of the seat belt and the proportionality coefficient of mass flow rate of the inflator were used for optimization. The objective was to minimize the injury risk probability subjected to constraints of occupant injury indicator values for various body regions as specified in US-NCAP frontal impact tests requirements.