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In the United States and worldwide, 38,824 and 1.35 million people were killed in vehicle crashes during 2020. These statistics are tragic and indicative of an on-going public health crisis centered on automobiles and other ground transportation solutions. Although the long-term US vehicle fatality rate is slowly declining, it continues to be elevated compared to European countries. The introduction of vehicle safety systems and re-designed roadways has improved survivability and driving environment, but driver behavior has not been fully addressed. A non-confrontational approach is the evaluation of driver behavior using onboard sensors and computer algorithms to determine the vehicle’s “mistrust” level of the given operator and the safety of the individual operating the vehicle. This is an inversion of the classic human-machine trust paradigm in which the human evaluates whether the machine can safely operate in an automated fashion.