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Faced with one of the greatest challenges of humanity – climate change – the European Union has set out a strategy to achieve climate neutrality by 2050 as part of the European Green Deal. To date, extensive research has been conducted on the CO2 life cycle analysis of mobile propulsion systems. However, achieving absolute net-zero CO2 emissions requires the adjustment of the relevant key performance indicators for the development of mobile propulsion systems. In this context, research is presented that examines the ecological and economic sustainability impacts of a hydrogen-fueled mild hybrid vehicle, a hydrogen-fueled 48V hybrid vehicle, a methanol-fueled 400V hybrid vehicle, a methanol-to-gasoline-fueled plug-in hybrid vehicle, a battery electric vehicle, and a fuel cell electric vehicle. For this purpose, a combined Life-Cycle Assessment (LCA) and Life-Cycle Cost Assessment was performed for the different propulsion concepts.