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The majority of transportation systems have continued to be powered by the internal combustion engine and fossil fuels. Heavy-duty applications especially are reliant on diesel engines for their high brake efficiency, power density, and robustness. Although engineering developments have advanced engines towards significantly fewer emissions and higher efficiency, the use of fossil-derived diesel as fuel sets a fundamental threshold in the achievable total net carbon reduction. Dimethyl ether can be produced from various renewable feedstocks and has a high chemical reactivity making it suitable for heavy-duty applications, namely compression ignition direct injection engines. Literature shows the successful use of DME fuels in diesel engines without significant hardware modifications.