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The Orbiter Environmental Control and Life Support System (ECLSS) functioned successfully on 76 Shuttle missions to date. The ECLSS consists of six subsystems which provide both a habitable environment for the crew and active vehicle thermal control. The Orbiter ECLSS design is reviewed in this paper and the operational flight experience is summarized. Significant flight problems are described, along with the design or procedural changes implemented to resolve the problems. The design and flight experience is summarized for recent enhancements to the ECLSS to meet extended duration missions and to accommodate visits to the Mir Space Station and to the International Space Station.

NASA's Constellation Program includes the Orion, Altair, and Lunar Surface Systems (LSS) project offices. The first two elements, Orion and Altair, are manned space vehicles while the third element is broader and includes several subelements including Rovers and a Lunar Habitat. The upcoming planned missions involving these systems and vehicles include several risks and design challenges. Due to the unique thermal environment, many of these risks and challenges are associated with the vehicles' thermal control system. NASA's Exploration Systems Mission Directorate (ESMD) includes the Exploration Technology Development Program (ETDP). ETDP consists of several technology development projects. The project chartered with mitigating the aforementioned risks and design challenges is the Thermal Control System Development for Exploration Project.

In preparation for the contract award of the Crew Exploration Vehicle (CEV), the National Aeronautics and Space Administration (NASA) produced two design reference missions for the vehicle. The design references used teams of engineers across the agency to come up with two configurations. This process helped NASA understand the conflicts and limitations in the CEV design, and investigate options to solve them.