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In order to conserve mass and volume, it was proposed that the International Space Station (ISS) control the level of carbon dioxide (CO2) in the Space Shuttle Orbiter while the Orbiter is docked to the ISS. If successful, this would greatly reduce the number of lithium hydroxide (LiOH) canisters required for each ISS-related Orbiter mission. Because of the impact on the Orbiter Environmental Control and Life Support Subsystem (ECLSS), as well as on the Orbiter flight manifest, a Space Shuttle Program (SSP) analysis was necessary. STS-108 (ISS UF1) pre-flight analysis using the Personal Computer Thermal Analyzer Program (PCTAP) predicted that the ISS would be able to control the level of CO2 in the Orbiter (and throughout the stack) under nominal conditions with no supplemental LiOH required. This analysis assumed that the Carbon Dioxide Removal Assembly (CDRA) located in the U.S.

Crewmember ingress of the International Space Station (ISS) before that time accorded by the original ISS assembly sequence, and thus before the ISS capability to adequately control the levels of temperature, humidity, and carbon dioxide, poses significant impacts to ISS Environmental Control and Life Support (ECLS). Among the most significant considerations necessitated by early ingress are those associated with the capability of the Shuttle Transportation System (STS) Orbiter to control the aforementioned levels, the capability of the ISS to deliver the conditioned air among the ISS elements, and the definition and distribution of crewmember metabolic heat, carbon dioxide, and water vapor. Even under the assumption that all Orbiter and ISS elements would be operating as designed, condensation control and crewmember comfort were paramount issues preceding each of the ISS Missions 2A and 2A.1.

Since flight requirements often necessitate last-minute re-analysis, it became crucial to develop flexible and comprehensive transport phenomena analysis software that would quickly ensure all vehicle and payload requirements would be satisfied. The software would replace various mainframe-based software, such as the Thermal Radiation Analyzer System (TRASYS) and the Systems Improved Numerical Differencing Analyzer (SINDA). The software would need to have the flexibility to employ models that could be developed and modified as vehicle systems change. By use of event files which contain simple, intuitive commands, the characteristics of individual missions could be built as inputs to the model. By moving the Environmental Control & Life Support (ECLS) system model to the PC environment, each analyst would have execution, storage, and processing management control. And of course, software portability would be greatly increased.